ITK inhibitor 6
Product Specifications
UNSPSC Description
ITK inhibitor 6 (compound 43) is a potent and selective ITK inhibitor with IC50s of 4 nM, 133 nM, 320 nM, 2360 nM, 155 nM for ITK, BTK, JAK3, EGFR, LCK, respectively. ITK inhibitor 6 inhibits phosphorylation of PLCγ1 and ERK1/2. ITK inhibitor 6 shows antiproliferative activities[1].
Target Antigen
Itk
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/itk-inhibitor-6.html
Solubility
10 mM in DMSO
Smiles
C=CC(NCCOC1=C2C=C(NC2=CC(CC3=CC=CC=C3)=C1)C4=NNC5=C4C=CC(C(F)F)=C5)=O
Molecular Weight
486.51
References & Citations
[1]Wang X, et al. Design, synthesis and structure-activity relationship of indolylindazoles as potent and selective covalent inhibitors of interleukin-2 inducible T-cell kinase (ITK). Eur J Med Chem. 2020 Feb 1;187:111918.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-146672/ITK-inhibitor-6-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-146672/
Clinical Information
No Development Reported
CAS Number
2404604-06-2
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