ITK inhibitor 5
ITK inhibitor 5 (compound 27) is a potent and selective ITK inhibitor with IC50s of 5.6, 25 nM for ITK, BTK, respectively[1].
Product Specifications
CAS Number
2404603-41-2
UNSPSC
12352005
Target
Itk
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/itk-inhibitor-5.html
Solubility
10 mM in DMSO
Smiles
C=CC(NCCOC1=C2C=C(NC2=CC=C1)C3=NNC4=C3C=CC(C(F)F)=C4)=O
Molecular Formula
C21H18F2N4O2
Molecular Weight
396.39
References & Citations
[1]Wang X, et al. Design, synthesis and structure-activity relationship of indolylindazoles as potent and selective covalent inhibitors of interleukin-2 inducible T-cell kinase (ITK) . Eur J Med Chem. 2020 Feb 1;187:111918.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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