KDM5B-IN-3
KDM5B-IN-3 (Compound 5) is a histone lysine specific demethylase 5B (KDM5B/JARID1B) inhibitor with an IC50 of 9.32 μM. KDM5B-IN-3 can be used for the research of gastric cancer[1].
Product Specifications
CAS Number
[1385101-10-9]
UNSPSC
12352005
Hazard Statement
H315-H319-H320
Target
Histone Demethylase
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/kdm5b-in-3.html
Solubility
10 mM in DMSO
Smiles
CC(C1=NNC(C(NCC(N2CCOCC2)C3=C(C=CC=C3)Cl)=O)=C1)C
Molecular Formula
C19H25ClN4O2
Molecular Weight
376.88
Precautions
P264-P280-P302+P352-P305+P351+P338-P362
References & Citations
[1]Bing Zhao, et al. Discovery of pyrazole derivatives as cellular active inhibitors of histone lysine specific demethylase 5B (KDM5B/JARID1B) . Eur J Med Chem. 2020 Apr 15;192:112161.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
KDM5
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