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AChE/BChE-IN-8

AChE/BChE-IN-8 (Compound 5a) is an uncompetitive AChE and mixed BChE inhibitor with Ki values of 0.788 μM and 2.364 μM against Electrophorus electricus AChE (EeAChE) and equine BChE (eqBChE), respectively. AChE/BChE-IN-8 can cross the BBB and has low cytotoxicity[1].

Product Specifications

CAS Number

2421120-96-7

UNSPSC

12352005

Target

Cholinesterase (ChE)

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/ache-bche-in-8.html

Solubility

10 mM in DMSO

Smiles

CC1=C(C(C=CN1CCCCCCNCC2=CC=CC=C2)=O)OCC3=CC=CC=C3

Molecular Formula

C26H32N2O2

Molecular Weight

404.54

References & Citations

[1]Bortolami M, et al. New deferiprone derivatives as multi-functional cholinesterase inhibitors: design, synthesis and in vitro evaluation. Eur J Med Chem. 2020 Jul 15;198:112350.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

AChE; BChE

Frequently Asked Questions

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