AChE/BChE-IN-8
AChE/BChE-IN-8 (Compound 5a) is an uncompetitive AChE and mixed BChE inhibitor with Ki values of 0.788 μM and 2.364 μM against Electrophorus electricus AChE (EeAChE) and equine BChE (eqBChE), respectively. AChE/BChE-IN-8 can cross the BBB and has low cytotoxicity[1].
Product Specifications
CAS Number
2421120-96-7
UNSPSC
12352005
Target
Cholinesterase (ChE)
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ache-bche-in-8.html
Solubility
10 mM in DMSO
Smiles
CC1=C(C(C=CN1CCCCCCNCC2=CC=CC=C2)=O)OCC3=CC=CC=C3
Molecular Formula
C26H32N2O2
Molecular Weight
404.54
References & Citations
[1]Bortolami M, et al. New deferiprone derivatives as multi-functional cholinesterase inhibitors: design, synthesis and in vitro evaluation. Eur J Med Chem. 2020 Jul 15;198:112350.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AChE; BChE
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