POP-IN-1
POP-IN-1 (Compound 12h) is a potent inhibitor of POP with an Ki of 0.009 μM. POP-IN-1 has the potential for the research of neurodegenerative diseases and cancer progression[1].
Product Specifications
CAS Number
2743432-99-5
UNSPSC
12352005
Target
Prolyl Endopeptidase (PREP)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/pop-in-1.html
Solubility
10 mM in DMSO
Smiles
[H][C@@]12C[C@@H]3C[C@H]([C@@]1(OB(O2)C4CCCN4C(C5=C(C=CC=C5)SC)=O)C)C3(C)C
Molecular Formula
C22H30BNO3S
Molecular Weight
399.35
References & Citations
[1]Plescia J, et al. Discovery of covalent prolyl oligopeptidase boronic ester inhibitors. Eur J Med Chem. 2020 Jan 1;185:111783.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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