STAT3-IN-9

STAT3-IN-9 is a potent STAT3 inhibitor. STAT3-IN-9 inhibits the activation of STAT3 (Tyr705) without influencing the phosphorylation of STAT1 (Tyr701) . STAT3-IN-9 induces apoptosis and cell cycle arrest at the G2/M phase[1].

Product Specifications

CAS Number

[2987726-27-0]

UNSPSC

12352005

Target

Apoptosis; STAT

Type

Reference compound

Related Pathways

Apoptosis; JAK/STAT Signaling; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/stat3-in-9.html

Solubility

10 mM in DMSO

Smiles

COC1=CC(NC2=CC(C3=CC=NN3C)=CC4=C2OC(C(C)=O)=C4)=CC(OC)=C1

Molecular Formula

C22H21N3O4

Molecular Weight

391.42

References & Citations

[1]Wang F, et al. Identification of novel STAT3 inhibitors bearing 2-acetyl-7-phenylamino benzofuran scaffold for antitumour study. Bioorg Med Chem. 2020; 28 (24) :115822.