LpxC-IN-9

LpxC-IN-9 (compound 19) is a potent LpxC inhibitor. LpxC-IN-9 has antibacterial and hypotensive effects[1]. LpxC-IN-9 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Product Specifications

CAS Number

[2756125-46-7]

UNSPSC

12352005

Target

Bacterial

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/lpxc-in-9.html

Solubility

10 mM in DMSO

Smiles

CS[C@H](N(C=O)O)CN1N=NC2=C1C=CC(C#CC3=CC=C(C=C3)CN4CCOCC4)=C2

Molecular Formula

C23H25N5O3S

Molecular Weight

451.54

References & Citations

[1]Takeru Furuya, et al. N-Hydroxyformamide LpxC inhibitors, their in vivo efficacy in a mouse Escherichia coli infection model, and their safety in a rat hemodynamic assay. Bioorg Med Chem. 2020 Dec 15;28 (24) :115826.