LmCPB-IN-1
Product Specifications
UNSPSC Description
LmCPB-IN-1 (compound 35) is a potent and reversible covalent Leishmania mexicana cysteine protease B (LmCPB) inhibitor with a pKi of 9.7[1].
Target Antigen
Cathepsin; Parasite
Type
Reference compound
Related Pathways
Anti-infection;Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/lmcpb-in-1.html
Solubility
10 mM in DMSO
Smiles
CC(C[C@@H](C(N(N(C#N)C)C)=O)NC(C1=CC(C(C)(C)C)=NN1C)=O)C
Molecular Weight
362.47
References & Citations
[1]Jean F R Ribeiro, et al. Crystal structure of Leishmania mexicana cysteine protease B in complex with a high-affinity azadipeptide nitrile inhibitor. Bioorg Med Chem. 2020 Nov 15;28(22):115743.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-146649/LmCPB-IN-1-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-146649/
Clinical Information
No Development Reported
CAS Number
2151025-98-6
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