VIM-2-IN-1

VIM-2-IN-1 (compound 1dj) is a β-lactamase inhibitor with antibacterial activities. VIM-2-IN-1 has moderate IC50 values of 23 µM, 48 µM and 231 µM for Verona integron-encoded metallo-β-lactamase (VIM-2), German imipenemase-1 (GIM-1) and New Delhi metallo-β-lactamase (NDM-1), respectively[1].

Product Specifications

CAS Number

[2452118-54-4]

UNSPSC

12352005

Target

Bacterial; Beta-lactamase

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/vim-2-in-1.html

Solubility

10 mM in DMSO

Smiles

CC(OCC1=C(N=NN1)CNS(=O)(C2=CC=C(C=C2)I)=O)=O

Molecular Formula

C12H13IN4O4S

Molecular Weight

436.23

References & Citations

[1] Zeeshan Muhammad, et al. Structural studies of triazole inhibitors with promising inhibitor effects against antibiotic resistance metallo-β-lactamases. Bioorg Med Chem. 2020 Aug 1;28 (15) :115598.