GLS1 Inhibitor-3

GLS1 Inhibitor-3 (compound C147) is a potent GLS1 inhibitor with an IC50 of 27.98 nM. GLS1 Inhibitor-3 shows antiproliferative activity[1].

Product Specifications

CAS Number

[2435781-94-3]

UNSPSC

12352005

Target

Glutaminase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/gls1-inhibitor-3.html

Solubility

10 mM in DMSO

Smiles

CC1=CC=C(C=C1)CN2C=C(N=N2)CCC(NC3=CC=C(N=N3)CCCCC4=NN=C(S4)NC(CC5=NC=CC=C5)=O)=O

Molecular Formula

C30H32N10O2S

Molecular Weight

596.71

References & Citations

[1]Xu X, et al. Discovery of novel glutaminase 1 allosteric inhibitor with 4-piperidinamine linker and aromatic heterocycles. Eur J Med Chem. 2022 Jun 5;236:114337.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Curated Selection

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