FtsZ-IN-1

FtsZ-IN-1 is a potent FtsZ inhibitor with quinolinium ring. FtsZ-IN-1 has stronger antibacterial activity against Gram-positive bacteria with MICs of 0.5-8 μg/mL. FtsZ-IN-1 significantly causes cell elongation of B. subtilis by enhancing FtsZ polymerization. FtsZ-IN-1 exhibits low hemolytic toxicity and low tendency to induce agent resistance. FtsZ-IN-1 has against drug-resistant bacteria activity[1].

Product Specifications

CAS Number

[2516246-24-3]

UNSPSC

12352005

Target

Bacterial

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/ftsz-in-1.html

Solubility

10 mM in DMSO

Smiles

CC1CCN(C2=C3C=CC=CC3=[N+](C)C(/C=C/C4=CC=C(N(C)C)C=C4)=C2)CC1.[I-]

Molecular Formula

C26H32IN3

Molecular Weight

513.46

References & Citations

[1]Zhong DX, She MT, Guo XC, et al. Design and synthesis of quinolinium-based derivatives targeting FtsZ for antibacterial evaluation and mechanistic study. Eur J Med Chem. 2022;236:114360.