Haspin-IN-2
Haspin-IN-2 (compound 4) is a potent and selective haspin inhibitor with an IC50 of 50 nM. Haspin-IN-1 also inbibits CLK1 and DYRK1A with IC50s of 445 nM and 917 nM, respectively[1].
Product Specifications
CAS Number
[2768474-47-9]
UNSPSC
12352005
Target
CDK; DYRK; Haspin Kinase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/haspin-in-2.html
Solubility
10 mM in DMSO
Smiles
COC1=NC2=C(C3=C(C=C2C=N1)C=NC=C3)[N+]([O-])=O
Molecular Formula
C12H8N4O3
Molecular Weight
256.22
References & Citations
[1]Wael Zeinyeh, et al. Synthesis and biological evaluation of Haspin inhibitors: Kinase inhibitory potency and cellular activity. Eur J Med Chem. 2022 Jun 5;236:114369.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CLK; DYRK1
Curated Selection
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