Haspin-IN-2

Haspin-IN-2 (compound 4) is a potent and selective haspin inhibitor with an IC50 of 50 nM. Haspin-IN-1 also inbibits CLK1 and DYRK1A with IC50s of 445 nM and 917 nM, respectively[1].

Product Specifications

CAS Number

[2768474-47-9]

UNSPSC

12352005

Target

CDK; DYRK; Haspin Kinase

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/haspin-in-2.html

Solubility

10 mM in DMSO

Smiles

COC1=NC2=C(C3=C(C=C2C=N1)C=NC=C3)[N+]([O-])=O

Molecular Formula

C12H8N4O3

Molecular Weight

256.22

References & Citations

[1]Wael Zeinyeh, et al. Synthesis and biological evaluation of Haspin inhibitors: Kinase inhibitory potency and cellular activity. Eur J Med Chem. 2022 Jun 5;236:114369.