Haspin-IN-1

Haspin-IN-1 (compound 2a) is a haspin inhibitor with an IC50 of 119 nM. Haspin-IN-1 also inbibits CLK1 and DYRK1A with IC50s of 221 nM and 916.3 nM, respectively[1].

Product Specifications

CAS Number

[2768474-30-0]

UNSPSC

12352005

Target

CDK; DYRK; Haspin Kinase

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/haspin-in-1.html

Solubility

10 mM in DMSO

Smiles

CSC1=NC2=C(C3=C(C=C2C=N1)C=NC=C3)[N+]([O-])=O

Molecular Formula

C12H8N4O2S

Molecular Weight

272.28

References & Citations

[1]Wael Zeinyeh, et al. Synthesis and biological evaluation of Haspin inhibitors: Kinase inhibitory potency and cellular activity. Eur J Med Chem. 2022 Jun 5;236:114369.