Cathepsin C-IN-3
Product Specifications
UNSPSC Description
Cathepsin C-IN-3 (compound SF11) is a potent Cathepsin C (Cat C) inhibitor, with an IC50 of 61.79 nM. Cathepsin C-IN-3 also inhibits THP-1 and U937 cell, with IC50 values of 101.5 and 86.5 nM, respectively[1].
Target Antigen
Cathepsin
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/cathepsin-c-in-3.html
Solubility
10 mM in DMSO
Smiles
CC(NC1=CC=C(C=C1)C2=C(N=C(N=C2)NC3=NC=C(C=C3)C4=CSC=C4)NC5=CC(C(F)(F)F)=CC=C5)=O
Molecular Weight
546.57
References & Citations
[1]Chen X, et al. Non-peptidyl non-covalent cathepsin C inhibitoEEr bearing a unique thiophene-substituted pyridine: Design, structure-activity relationship and anti-inflammatory activity in vivo. Eur J Med Chem. 2022 Jun 5;236:114368.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-146580/Cathepsin-C-IN-3-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-146580/
Clinical Information
No Development Reported
CAS Number
2825567-71-1
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