Keap1-Nrf2-IN-7
Keap1-Nrf2-IN-7 (compound 7v) is a potent Keap1-Nrf2 PPI (Keap1-Nrf2 protein−protein interaction) inhibitor with an IC50 of 0.45 µM[1].
Product Specifications
CAS Number
[2769963-42-8]
UNSPSC
12352005
Target
Keap1-Nrf2
Type
Reference compound
Related Pathways
NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/keap1-nrf2-in-7.html
Solubility
10 mM in DMSO
Smiles
CC1=CC=C(C=C1)S(=O)(N(C2=CC=C(C(OCC3=CC=C(C=C3)F)=C2)N(S(=O)(C4=CC=C(C=C4)C)=O)CC(O)=O)CC(O)=O)=O
Molecular Formula
C31H29FN2O9S2
Molecular Weight
656.70
References & Citations
[1]Lee S, et al. Structure-activity relationships of 1,4-bis (arylsulfonamido) -benzene or naphthalene-N, N'-diacetic acids with varying C2-substituents as inhibitors of Keap1-Nrf2 protein-protein interaction. Eur J Med Chem. 2022 Jul 5;237:114380.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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