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AKR1C3-IN-8

AKR1C3-IN-8 (Compound 5) is a potent, selective AKR1C3 inhibitor with an IC50 of 0.069 μM. AKR1C3-IN-8 shows antitumor activity[1].

Product Specifications

UNSPSC

12352005

Target

17β-HSD; Aldose Reductase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/akr1c3-in-8.html

Solubility

10 mM in DMSO

Smiles

COC1=CC=C(C=C1)CN2N=NC(O)=C2C(NC3=CC(C4=CC=CC=C4)=CC=C3)=O

Molecular Formula

C23H20N4O3

Molecular Weight

400.43

References & Citations

[1]Pippione AC, et al. New aldo-keto reductase 1C3 (AKR1C3) inhibitors based on the hydroxytriazole scaffold. Eur J Med Chem. 2022 Jul 5;237:114366.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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