AKR1C3-IN-6
AKR1C3-IN-6 (Compound 1) is a potent, selective AKR1C3 inhibitor with IC50 values of 0.31 μM and 73.23 μM against AKR1C3 and AKR1C2, respectively. AKR1C3-IN-6 shows antitumor activity[1].
Product Specifications
CAS Number
2137881-54-8
UNSPSC
12352005
Target
17β-HSD; Aldose Reductase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/akr1c3-in-6.html
Solubility
10 mM in DMSO
Smiles
COC1=CC=C(C=C1)CN2N=NC(O)=C2C(NC3=CC(C(F)(F)F)=CC=C3)=O
Molecular Formula
C18H15F3N4O3
Molecular Weight
392.33
References & Citations
[1]Pippione AC, et al. New aldo-keto reductase 1C3 (AKR1C3) inhibitors based on the hydroxytriazole scaffold. Eur J Med Chem. 2022 Jul 5;237:114366.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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