AKR1C3-IN-6
AKR1C3-IN-6 (Compound 1) is a potent, selective AKR1C3 inhibitor with IC50 values of 0.31 μM and 73.23 μM against AKR1C3 and AKR1C2, respectively. AKR1C3-IN-6 shows antitumor activity[1].
Product Specifications
CAS Number
2137881-54-8
UNSPSC
12352005
Target
17β-HSD; Aldose Reductase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/akr1c3-in-6.html
Solubility
10 mM in DMSO
Smiles
COC1=CC=C(C=C1)CN2N=NC(O)=C2C(NC3=CC(C(F)(F)F)=CC=C3)=O
Molecular Formula
C18H15F3N4O3
Molecular Weight
392.33
References & Citations
[1]Pippione AC, et al. New aldo-keto reductase 1C3 (AKR1C3) inhibitors based on the hydroxytriazole scaffold. Eur J Med Chem. 2022 Jul 5;237:114366.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
PA1860-Fluoro488 100 µg/Vial
Anti-SHP2/PTPN11 Antibody Picoband® Fluoro488 Conjugated
Sign In for Pricing
View Details 46815124 3x 1.0µg DNA
TMC1 CRISPRa sgRNA lentivector (set of three targets)(Mouse)
Sign In for Pricing
View Details 
RC201183L1V 200 µL
BTN3A2 (NM_007047) Human Tagged ORF Clone Lentiviral Particle
Sign In for Pricing
View Details MBS6375157-01 0.1 mL
CXADR (Coxsackievirus And Adenovirus Receptor, Coxsackievirus B-adenovirus Receptor, HCVADR, CVB3-binding Protein, CAR) (MaxLight 650)
Sign In for Pricing
View Details MBS6375157-02 5x 0.1 mL
CXADR (Coxsackievirus And Adenovirus Receptor, Coxsackievirus B-adenovirus Receptor, HCVADR, CVB3-binding Protein, CAR) (MaxLight 650)
Sign In for Pricing
View Details