Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

DNA-PK-IN-8

DNA-PK-IN-8 is a highly potent, selective and orally active DNA-dependent protein kinase (DNA-PK) inhibitor with an IC50 value of 0.8 nM. DNA-PK-IN-8 exhibits synergistic antiproliferative activity against a series of cancer cell lines and significantly suppresses HL-60 tumor growth, when using in combination with Doxorubicin[1].

Product Specifications

CAS Number

2823369-81-7

UNSPSC

12352005

Target

DNA-PK

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; PI3K/Akt/mTOR

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/dna-pk-in-8.html

Purity

99.74

Solubility

10 mM in DMSO

Smiles

CC1=CC2=NC=NN2C=C1NC3=NC=C4C(N(CC(N4C)=O)C5CCOCC5)=N3

Molecular Formula

C19H22N8O2

Molecular Weight

394.43

References & Citations

[1]Ding Z, et al. Discovery of novel 7,8-dihydropteridine-6 (5H) -one-based DNA-PK inhibitors as potential anticancer agents via scaffold hopping strategy. Eur J Med Chem. 2022;237:114401.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, stored under nitrogen, away from moisture)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

More Discoveries

Explore Other Products

Browse additional items from our catalog

50mL Bulk Wrap PVC
SLS9524 100 / PCK

50mL Bulk Wrap PVC

Sign In for Pricing
View Details
PLCB1-IT1 Protein Vector (Human) (pPM-C-His)
PV111737 500 ng

PLCB1-IT1 Protein Vector (Human) (pPM-C-His)

Sign In for Pricing
View Details
PGM1 Recombinant Antibody, Cy7 Conjugated
bsm-62730R-Cy7-01 20 µL

PGM1 Recombinant Antibody, Cy7 Conjugated

Sign In for Pricing
View Details
PGM1 Recombinant Antibody, Cy7 Conjugated
bsm-62730R-Cy7-02 100 µL

PGM1 Recombinant Antibody, Cy7 Conjugated

Sign In for Pricing
View Details
Geranylgeranyl Diphosphate Synthase 1 (GGPS1) Antibody (HRP)
abx303949-01 20 µg

Geranylgeranyl Diphosphate Synthase 1 (GGPS1) Antibody (HRP)

Sign In for Pricing
View Details
Geranylgeranyl Diphosphate Synthase 1 (GGPS1) Antibody (HRP)
abx303949-02 50 µg

Geranylgeranyl Diphosphate Synthase 1 (GGPS1) Antibody (HRP)

Sign In for Pricing
View Details