DNA-PK-IN-8
DNA-PK-IN-8 is a highly potent, selective and orally active DNA-dependent protein kinase (DNA-PK) inhibitor with an IC50 value of 0.8 nM. DNA-PK-IN-8 exhibits synergistic antiproliferative activity against a series of cancer cell lines and significantly suppresses HL-60 tumor growth, when using in combination with Doxorubicin[1].
Product Specifications
CAS Number
[2823369-81-7]
UNSPSC
12352005
Target
DNA-PK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/dna-pk-in-8.html
Purity
99.74
Solubility
10 mM in DMSO
Smiles
CC1=CC2=NC=NN2C=C1NC3=NC=C4C(N(CC(N4C)=O)C5CCOCC5)=N3
Molecular Formula
C19H22N8O2
Molecular Weight
394.43
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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