RmlA-IN-1
RmlA-IN-1 (Compound 8a) is a potent inhibitor of glucose-1-phosphate thymidylyltransferase (RmlA) with an IC50 of 0.073 μM. RmlA-IN-1 influences monosaccharide l-Rhamnose biosynthetic pathway. RmlA-IN-1 affects bacterial cell wall permeability[1].
Product Specifications
CAS Number
1415030-78-2
UNSPSC
12352005
Target
Bacterial
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/rmla-in-1.html
Solubility
10 mM in DMSO
Smiles
CN(S(=O)(C1=CC=CC=C1)=O)C2=C(N(C(NC2=O)=O)CC3=CC=CC=C3)N
Molecular Formula
C18H18N4O4S
Molecular Weight
386.42
References & Citations
[1]Xiao G, et al. Next generation Glucose-1-phosphate thymidylyltransferase (RmlA) inhibitors: An extended SAR study to direct future design. Bioorg Med Chem. 2021;50:116477.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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