KRAS inhibitor-16
KRAS inhibitor-16 (compound 3-11) is a potent KRAS G12C inhibitor with an IC50 of 0.457 µM. KRAS inhibitor-16 shows p-ERK inhibition activities with IC50s of 3.06, 11.1 µM in MIA PaCA-2, A549 cells, respectively. KRAS inhibitor-16 has the potential for the research of pancreatic, colorectal, and lung cancers[1].
Product Specifications
CAS Number
2230873-67-1
UNSPSC
12352005
Target
Ras
Type
Reference compound
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/kras-inhibitor-16.html
Solubility
10 mM in DMSO
Smiles
C=CC(N1CCN(CC1)C2=C3C=C(C(C4=CC(O)=CC=C4Cl)=C(C3=NS2)F)Cl)=O
Molecular Formula
C20H16Cl2FN3O2S
Molecular Weight
452.33
References & Citations
[1]Brian Alan LANMAN, et al. Kras g12c inhibitors and methods of using the same. US20180334454A1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
K-Ras
Frequently Asked Questions
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