FGFR4-IN-10
Product Specifications
UNSPSC Description
FGFR4-IN-10 (compound 5a) is a potent and selective FGFR4 inhibitor with an IC50 value of 70.7 nM. FGFR4-IN-10 shows no inhibition against other FGFR family members, i.e. FGFR1, FGFR2 and FGFR3[1].
Target Antigen
FGFR
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/fgfr4-in-10.html
Solubility
10 mM in DMSO
Smiles
COCCNC1=C(C=NC(NC(N2CCCC3=CC=C(N=C32)C(C(F)(F)F)=O)=O)=C1)C#N
Molecular Weight
448.40
References & Citations
[1]Zhen Zhang, et al. Characterization of an aromatic trifluoromethyl ketone as a new warhead for covalently reversible kinase inhibitor design. Bioorg Med Chem. 2021 Nov 15;50:116457.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-146541/FGFR4-IN-10-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-146541/
Clinical Information
No Development Reported
CAS Number
2857862-25-8
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