FGFR4-IN-10

FGFR4-IN-10 (compound 5a) is a potent and selective FGFR4 inhibitor with an IC50 value of 70.7 nM. FGFR4-IN-10 shows no inhibition against other FGFR family members, i.e. FGFR1, FGFR2 and FGFR3[1].

Product Specifications

CAS Number

[2857862-25-8]

UNSPSC

12352005

Target

FGFR

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/fgfr4-in-10.html

Solubility

10 mM in DMSO

Smiles

COCCNC1=C(C=NC(NC(N2CCCC3=CC=C(N=C32)C(C(F)(F)F)=O)=O)=C1)C#N

Molecular Formula

C20H19F3N6O3

Molecular Weight

448.40

References & Citations

[1]Zhen Zhang, et al. Characterization of an aromatic trifluoromethyl ketone as a new warhead for covalently reversible kinase inhibitor design. Bioorg Med Chem. 2021 Nov 15;50:116457.