HDAC-IN-35
HDAC-IN-35 (Compound 14) is a potent, selective HDAC and VEGFR-2 inhibitor, with IC50 values of 0.166 and 13.2 μM for HDAC6 and VEGFR-2, respectively[1].
Product Specifications
UNSPSC
12352005
Target
HDAC; VEGFR
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hdac-in-35.html
Solubility
10 mM in DMSO
Smiles
O=C(NO)/C=C/C1=CC=C(C=C1)NC(NC2=CC=C(C(C(F)(F)F)=C2)Cl)=O
Molecular Formula
C17H13ClF3N3O3
Molecular Weight
399.75
References & Citations
[1]Szu Lee, et al. Effect of phenylurea hydroxamic acids on histone deacetylase and VEGFR-2. Bioorg Med Chem. 2021 Nov 15;50:116454.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HDAC1; HDAC6; HDAC8; VEGFR2/KDR/Flk-1
Curated Selection
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