KRAS inhibitor-12

KRAS inhibitor-12 (compound 6-1) is a potent KRAS G12C inhibitor with an IC50 of 0.537 µM. KRAS inhibitor-12 shows p-ERK inhibition activities with IC50s of 1.3, 3.7 µM in MIA PaCA-2, A549 cells, respectively. KRAS inhibitor-12 has the potential for the research of pancreatic, colorectal, and lung cancers[1].

Product Specifications

CAS Number

[2230874-00-5]

UNSPSC

12352005

Target

Ras

Type

Reference compound

Related Pathways

GPCR/G Protein; MAPK/ERK Pathway

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/kras-inhibitor-12.html

Solubility

10 mM in DMSO

Smiles

O=C(N1CCN(CC1)C2=C3C=C(Cl)C(C4=C(Cl)C=CC(N)=N4)=C(F)C3=NS2)C=C

Molecular Formula

C19H16Cl2FN5OS

Molecular Weight

452.33

References & Citations

[1]Brian alan, et al. KRAS g12c inhibitors and methods of using the same. WO2018119183 A2

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

K-Ras

Curated Selection

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