IsoCA-4
IsoCA-4, a Combretastatin A4 derivative, is a tubulin polymerization inhibitor. isoCA-4 has anti-proliferative activities[1].
Product Specifications
CAS Number
[1067880-31-2]
UNSPSC
12352005
Target
Microtubule/Tubulin
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/isoca-4.html
Solubility
10 mM in DMSO
Smiles
C=C(C1=CC(OC)=C(C(OC)=C1)OC)C2=CC(O)=C(C=C2)OC
Molecular Formula
C18H20O5
Molecular Weight
316.35
References & Citations
[1]Xiang-Yu Yan, et al. Design, synthesis, and biological evaluation of novel diphenylamine derivatives as tubulin polymerization inhibitors targeting the colchicine binding site. Eur J Med Chem. 2022 Apr 16;237:114372.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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