Retinoic acid-d6

Retinoic acid-d6 is the deuterium labeled Retinoic acid[1]. Retinoic acid is a metabolite of vitamin A that plays important roles in cell growth, differentiation, and organogenesis. Retinoic acid is a natural agonist of RAR nuclear receptors, with IC50s of 14 nM for RARα/β/γ. Retinoic acid bind to PPARβ/δ with Kd of 17 nM. Retinoic acid acts as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha[2][3][4][5][6][7].

Product Specifications

CAS Number

[2483831-72-5]

Product Name Alternative

Vitamin A acid-d6; all-trans-Retinoic acid-d6; ATRA-d6

UNSPSC

12352211

Hazard Statement

H302, H315, H360, H410

Target

Autophagy; Endogenous Metabolite; Isotope-Labeled Compounds; PPAR; RAR/RXR

Type

Isotope-Labeled Compounds

Related Pathways

Autophagy; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Others; Vitamin D Related/Nuclear Receptor

Applications

Cancer-programmed cell death

Field of Research

Cancer

Purity

98.9

Solubility

10 mM in DMSO

Smiles

OC(/C=C(C([2H])([2H])[2H])/C=C/C=C(C([2H])([2H])[2H])/C=C/C1=C(C)CCCC1(C)C)=O

Molecular Formula

C20H22D6O2

Molecular Weight

306.47

Precautions

H302, H315, H360, H410

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Wu L, et al. Retinoid X Receptor Agonists Upregulate Genes Responsible for the Biosynthesis of All-Trans-Retinoic Acid in Human Epidermis. PLoS One. 2016 Apr 14;11 (4) :e0153556.