Topoisomerase I inhibitor 7
Product Specifications
UNSPSC Description
Topoisomerase I inhibitor 7 (Compound 8) is a potent inhibitor of Topoisomerase I. Topoisomerase I inhibitor 7 significantly inhibits tumor growth (up to 79%) and increases the lifespan (153%) of mice bearing P388 lymphoma transplants. Topoisomerase I inhibitor 7 indicates prospects for further search of new antitumor agent candidates among the heteroarene-fused anthraquinones[1].
Target Antigen
Topoisomerase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/topoisomerase-i-inhibitor-7.html
Solubility
10 mM in DMSO
Smiles
CC1=C(C2=C(C3=C(C(O)=C2N1)C(C4=C(C3=O)C=CC=C4)=O)O)C(N5CC[C@@H](C5)N)=O
Molecular Weight
405.40
References & Citations
[1]Tikhomirov AS, et al. Amides of pyrrole- and thiophene-fused anthraquinone derivatives: A role of the heterocyclic core in antitumor properties. Eur J Med Chem. 2020 Aug 1;199:112294.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-146497/Topoisomerase-I-inhibitor-7-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-146497/
Clinical Information
No Development Reported
CAS Number
2408639-81-4
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