VEGFR-2/BRAF-IN-2
Product Specifications
UNSPSC Description
VEGFR-2/BRAF-IN-2 (Compound 4a) is a dual VEGFR-2 and BRAF kinases inhibitor with IC50 values of 0.111, 0.089 and 0.071 µM against VEGFR-2, BRAFV600E and BRAFWT, respectively. VEGFR-2/BRAF-IN-2 induces apoptosis and arrests the cell cycle mainly in the G1 phase[1].
Target Antigen
Apoptosis; Raf; VEGFR
Type
Reference compound
Related Pathways
Apoptosis;MAPK/ERK Pathway;Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/vegfr-2-braf-in-2.html
Solubility
10 mM in DMSO
Smiles
FC(F)(F)C1=CC=CC(NC(NNC(CSC2=NC3=C(C4=C(S3)CCCC4)C(N2C5=CC=C(C=C5)Cl)=O)=O)=O)=C1
Molecular Weight
608.05
References & Citations
[1]Hassan RA, et al. Novel antiproliferative agents bearing substituted thieno[2,3-d]pyrimidine scaffold as dual VEGFR-2 and BRAF kinases inhibitors and apoptosis inducers; design, synthesis and molecular docking. Bioorg Chem. 2022 May 10;125:105861.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-146492/VEGFR-2-BRAF-IN-2-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-146492/
Clinical Information
No Development Reported
Curated Selection
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