Anti-Aβ agent 1A
Product Specifications
UNSPSC Description
Anti-Aβ agent 1A (compound M15) has potent activity against amyloid-β. Anti-Aβ agent 1A possesses can significantly inhibit LPS-induced levels of IL-1β, IL-6 and TNF-α, and reduces the apoptosis of SH-SY5Y induced by H2O2 through mitochondria pathway. Anti-Aβ agent 1A possesses antioxidant, anti-inflammatory, anti-Aβ toxicity and neuroprotective activities. Anti-Aβ agent 1A can be used for researching Alzheimer’s disease (AD)[1].
Target Antigen
Amyloid-β
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/anti-aβ-agent-1a.html
Solubility
10 mM in DMSO
Smiles
C[C@@]12[C@]3([H])[C@](O[C@]4(CC[C@H](CO4)C)[C@H]3C)([H])C[C@@]1([H])[C@@]5([H])[C@]([C@@]6(C(C[C@H](CC6)OC(NCC7=CC=CC=C7)=O)=CC5)C)([H])CC2
Molecular Weight
547.77
References & Citations
[1]Yang GX,et al. Design, synthesis and evaluation of diosgenin carbamate derivatives as multitarget anti-Alzheimer's disease agents. Eur J Med Chem. 2020 Feb 1;187:111913.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-146483/Anti-Aβ-agent-1A-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-146483/
Clinical Information
No Development Reported
CAS Number
9007-83-4
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
MBS6345734-01 0.2 mL
SEC14L4, NT (SEC14L4, TAP3, SEC14-like protein 4, Tocopherol-associated protein 3) (AP)
Ask
View Details MBS6345734-02 5x 0.2 mL
SEC14L4, NT (SEC14L4, TAP3, SEC14-like protein 4, Tocopherol-associated protein 3) (AP)
Ask
View Details 