Anti-Aβ agent 1A

Anti-Aβ agent 1A (compound M15) has potent activity against amyloid-β. Anti-Aβ agent 1A possesses can significantly inhibit LPS-induced levels of IL-1β, IL-6 and TNF-α, and reduces the apoptosis of SH-SY5Y induced by H2O2 through mitochondria pathway. Anti-Aβ agent 1A possesses antioxidant, anti-inflammatory, anti-Aβ toxicity and neuroprotective activities. Anti-Aβ agent 1A can be used for researching Alzheimer’s disease (AD) [1].

Product Specifications

CAS Number

[2313346-53-9]

UNSPSC

12352005

Target

Amyloid-β

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/anti-aβ-agent-1a.html

Solubility

10 mM in DMSO

Smiles

C[C@@]12[C@]3([H])[C@](O[C@]4(CC[C@H](CO4)C)[C@H]3C)([H])C[C@@]1([H])[C@@]5([H])[C@]([C@@]6(C(C[C@H](CC6)OC(NCC7=CC=CC=C7)=O)=CC5)C)([H])CC2

Molecular Formula

C35H49NO4

Molecular Weight

547.77

References & Citations

[1]Yang GX, et al. Design, synthesis and evaluation of diosgenin carbamate derivatives as multitarget anti-Alzheimer's disease agents. Eur J Med Chem. 2020 Feb 1;187:111913.