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EGFR-IN-53

EGFR-IN-53 (Compound 7) is a potent EGFR inhibitor with an IC50 of 8.264 µM. EGFR-IN-53 shows cytotoxic activity against cancer cell lines[1].

Product Specifications

CAS Number

2418549-33-2

UNSPSC

12352005

Target

EGFR

Type

Reference compound

Related Pathways

JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/egfr-in-53.html

Solubility

10 mM in DMSO

Smiles

S=C(NC1=CC=C2OCOC2=C1)NNC3=CC=CC=C3

Molecular Formula

C14H13N3O2S

Molecular Weight

287.34

References & Citations

[1]Abbas SY, et al. Synthesis and anticancer activity of thiourea derivatives bearing a benzodioxole moiety with EGFR inhibitory activity, apoptosis assay and molecular docking study. Eur J Med Chem. 2020 Jul 15;198:112363.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

EGFR/ErbB1/HER1

Frequently Asked Questions

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