EGFR-IN-51
Product Specifications
UNSPSC Description
EGFR-IN-51 (Compound 6) is a potent EGFR inhibitor with IC50 values of 0.493, 102.60 and 461.63 µM against EGFR, EGFR L858R-TK and EGFR T790M-TK, respectively. EGFR-IN-51 shows cytotoxic activity against cancer cell lines and induces apoptosis[1].
Target Antigen
Apoptosis; EGFR
Type
Reference compound
Related Pathways
Apoptosis;JAK/STAT Signaling;Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/egfr-in-51.html
Solubility
10 mM in DMSO
Smiles
S=C(NC1=C2C=CC=CC2=NC3=C1C=CC=C3)NC4=CC=C5OCOC5=C4
Molecular Weight
373.43
References & Citations
[1]Abbas SY, et al. Synthesis and anticancer activity of thiourea derivatives bearing a benzodioxole moiety with EGFR inhibitory activity, apoptosis assay and molecular docking study. Eur J Med Chem. 2020 Jul 15;198:112363.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-146471/EGFR-IN-51-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-146471/
Clinical Information
No Development Reported
CAS Number
2418549-32-1
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
