DPP-4/GPR119 modulator 1
Product Specifications
UNSPSC Description
DPP-4/GPR119 modulator 1 (Compound 22) is an orally active dipeptidyl peptidase IV (DPP-IV) inhibitor and GPR119 agonist. DPP-4/GPR119 modulator 1 shows blood glucose-lowering effect and moderate inhibition on hERG channel with an IC50 of 4.9 μM. DPP-4/GPR119 modulator 1 can be used for diabetes research[1][1]. DPP-4/GPR119 modulator 1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Target Antigen
Dipeptidyl Peptidase; GPR119; Potassium Channel
Type
Reference compound
Related Pathways
GPCR/G Protein;Membrane Transporter/Ion Channel;Metabolic Enzyme/Protease;Neuronal Signaling
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/dpp-4-gpr119-modulator-1.html
Solubility
10 mM in DMSO
Smiles
CC#CCN1C(N2CCC[C@H](C2)N)=NC3=C1C(N(C(N3C)=O)CCCN4CCN(CC4)C5=NC(C6=CC=CC=C6)=NO5)=O.Cl
Molecular Weight
623.15
References & Citations
[1]Li G, et al. The optimization of xanthine derivatives leading to HBK001 hydrochloride as a potent dual ligand targeting DPP-IV and GPR119. Eur J Med Chem. 2020 Feb 15;188:112017.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-146468/DPP-4-GPR119-modulator-1-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-146468/
Clinical Information
No Development Reported
CAS Number
2411099-68-6
Curated Selection
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