NusB-IN-1
Product Specifications
UNSPSC Description
NusB-IN-1 (Compound 22r) is a potent, orally active bacterial rRNA synthesis inhibitor. NusB-IN-1 shows antimicrobial activity against MRSA and VRSA[1]. NusB-IN-1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Target Antigen
Bacterial; DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Anti-infection;Cell Cycle/DNA Damage
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/nusb-in-1.html
Solubility
10 mM in DMSO
Smiles
O=[N+](C1=CC(CNC2=C(C=CC=C2)C#CC3=CC=CC=C3)=C(C=C1)O)[O-]
Molecular Weight
344.36
References & Citations
[1]Qiu Y, et al. Synthesis and biological evaluation of nusbiarylin derivatives as bacterial rRNA synthesis inhibitor with potent antimicrobial activity against MRSA and VRSA. Bioorg Chem. 2022 Jul;124:105863.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-146463/NusB-IN-1-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-146463/
Clinical Information
No Development Reported
CAS Number
2923738-92-3
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