Anticancer agent 58
Product Specifications
UNSPSC Description
Anticancer agent 58 (compound 16) has inhibitory activity against kinds of cancer cell lines, especially in A549 and T24 with IC50s of 0.6 μM and 0.7 μM, respectively. Anticancer agent 58 induces apoptosis by activating caspase 3/8/9 activity, and induces an increase of Ca2+ and ROS in cancer cells. Anticancer agent 58 significantly decreases mitochondrial membrane potential. Anticancer agent 58 can suppress tumor growth in T24 mouse xenograft model[1].
Target Antigen
Apoptosis; Caspase; ROS Kinase
Type
Reference compound
Related Pathways
Apoptosis;Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/anticancer-agent-58.html
Solubility
10 mM in DMSO
Smiles
[H][C@](CC1=CC=CC=C1)(C(O[C@H]2CC[C@]3(C(C2(C)C)CC[C@@]4(C3C(C=C5[C@]4(CC[C@]6(CC[C@](C(O)=O)(C[C@@]56[H])C)C)C)=O)C)C)=O)N
Molecular Weight
617.86
References & Citations
[1]Yin Y, et al. Synthesis and in vitro/in vivo anticancer evaluation of pentacyclic triterpenoid derivatives linked with l-phenylalanine or l-proline [published online ahead of print, 2022 May 11]. Bioorg Chem. 2022;126:105865.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-146461/Anticancer-agent-58-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-146461/
Clinical Information
No Development Reported
CAS Number
9007-83-4
Curated Selection
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