Antibacterial agent 102

Antibacterial agent 102 (compound 32) possesses potent in vitro and in vivo antibacterial activity, with MICs Staphylococcus aureus (S. aureus) . Antibacterial agent 102 also moderately inhibits CYP3A4 with an IC50 value of 6.148 μM. Antibacterial agent 102 can reduce Methicillin-resistant Staphylococcus aureus (MRSA) load in thigh infected mice[1].

Product Specifications

CAS Number

[2413293-65-7]

UNSPSC

12352005

Target

Bacterial; Cytochrome P450

Type

Reference compound

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/antibacterial-agent-102.html

Solubility

10 mM in DMSO

Smiles

O=C(O[C@H]1[C@]2(C)[C@@H](CC[C@]3([C@H]([C@@H]([C@](C=C)(C1)C)O)C)[C@]2(C(CC3)=O)[H])C)CSC4=C(NC(CN5C=C(CN(C)C)N=N5)=O)C=CC=C4

Molecular Formula

C35H49N5O5S

Molecular Weight

651.86

References & Citations

[1]Zhang Z, et al. Design, synthesis and biological activities of novel pleuromutilin derivatives with a substituted triazole moiety as potent antibacterial agents. Eur J Med Chem. 2020;204:112604.