A3AR antagonist 1

A3AR antagonist 1 (compound 17) is a potent and selective human A3 adenosine receptor (AR) antagonist, with an Ki of 4.63 nM. A3AR antagonist 1 shows no affinity for the rat A3 AR even at high concentrations[1].

Product Specifications

CAS Number

[2413257-74-4]

UNSPSC

12352005

Target

Adenosine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/a3ar-antagonist-1.html

Solubility

10 mM in DMSO

Smiles

COC1=CC=C(C=C1)C(NC2=NC(C3=CC=CC=C3)=C(S2)C4=NC5=C(C(N4C6=CC=C(C=C6)OC)=O)C=CC=C5)=O

Molecular Formula

C32H24N4O4S

Molecular Weight

560.62

References & Citations

[1]Abdelrahman A, et, al. Substituted 4-phenylthiazoles: Development of potent and selective A 1, A 3 and dual A 1/A 3 adenosine receptor antagonists. Eur J Med Chem. 2020 Jan 15;186:111879.