A3AR antagonist 1
A3AR antagonist 1 (compound 17) is a potent and selective human A3 adenosine receptor (AR) antagonist, with an Ki of 4.63 nM. A3AR antagonist 1 shows no affinity for the rat A3 AR even at high concentrations[1].
Product Specifications
CAS Number
2413257-74-4
UNSPSC
12352005
Target
Adenosine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/a3ar-antagonist-1.html
Solubility
10 mM in DMSO
Smiles
COC1=CC=C(C=C1)C(NC2=NC(C3=CC=CC=C3)=C(S2)C4=NC5=C(C(N4C6=CC=C(C=C6)OC)=O)C=CC=C5)=O
Molecular Formula
C32H24N4O4S
Molecular Weight
560.62
References & Citations
[1]Abdelrahman A, et, al. Substituted 4-phenylthiazoles: Development of potent and selective A 1, A 3 and dual A 1/A 3 adenosine receptor antagonists. Eur J Med Chem. 2020 Jan 15;186:111879.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Adenosine A3 receptor (A3R)
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