Antiproliferative agent-6

Antiproliferative agent-6 (compound 8a) is a potent antitumor agent. Antiproliferative agent-6 has antiproliferative activity against cancer cell lines HCT116, MCF-7, H460 and non-tumor aneuploid immortal keratinocyte HaCaT cells with GI50s of 0.5 μM, 2 μM, 0.7 μM and 3.5 μM, respectively[1].

Product Specifications

CAS Number

[2389016-82-2]

UNSPSC

12352005

Target

DNA/RNA Synthesis

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/antiproliferative-agent-6.html

Solubility

10 mM in DMSO

Smiles

N#CC1=C(C2=C(N3C1=NC4=C3C=CC=C4)C=C(C=C2)F)N5C=C(N=N5)CCCCl

Molecular Formula

C21H14ClFN6

Molecular Weight

404.83

References & Citations

[1]Meščić Macan A, et al. Synthesis, antiproliferative activity and DNA/RNA-binding properties of mono- and bis- (1,2,3-triazolyl) -appended benzimidazo[1,2-a]quinoline derivatives. Eur J Med Chem. 2020;185:111845.