Anticancer agent 57

Anticancer agent 57 (compound 14) potently inhibits MDA-MB-231, MDA-MB-468, and MCF-7 cell lines, with IC50s of 6.43 ~ 8.00 μM. Anticancer agent 57 induces cell cycle arrest and significantly promotes apoptosis. Anticancer agent 57 inhibits tumor growth in nude mice xenografted with MADMB-231 cells. Anticancer agent 57 can be used for researching triple negative breast cancer (TNBC) [1].

Product Specifications

CAS Number

[2408017-71-8]

UNSPSC

12352005

Target

Apoptosis

Type

Reference compound

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/anticancer-agent-57.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=CC=CC(OC)=C1)/C=C/C2=CC=C(N(CCCl)CCCl)C=C2

Molecular Formula

C20H21Cl2NO2

Molecular Weight

378.29

References & Citations

[1]Elkhalifa D, et al. Design, synthesis, and validation of novel nitrogen-based chalcone analogs against triple negative breast cancer. Eur J Med Chem. 2020;187:111954.