PPARγ agonist 3
PPARγ agonist 3 (Compound 18a) is a potent and selective agonist of PPARγ. PPARγ agonist 3 is not cytotoxic neither on non-resistant nor on resistant cells. PPARγ agonist 3 exerts antitumor potency only in combination with Imatinib[1].
Product Specifications
CAS Number
2011801-48-0
UNSPSC
12352005
Target
PPAR
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pparγ-agonist-3.html
Solubility
10 mM in DMSO
Smiles
CCCC1=NC2=CC=CC=C2N1CC3=CC=C(C=C3)C4=CC=CC=C4C(N)=O
Molecular Formula
C24H23N3O
Molecular Weight
369.46
References & Citations
[1]Schoepf AM, et al. Overcoming imatinib resistance in chronic myelogenous leukemia cells using non-cytotoxic cell death modulators. Eur J Med Chem. 2020 Jan 1;185:111748.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
orb2921117-01 20 µg
Recombinant Listeria monocytogenes serovar 1/2a Cell wall teichoic acid glycosylation protein gtcA (gtcA)
Sign In for Pricing
View Details orb2921117-02 100 µg
Recombinant Listeria monocytogenes serovar 1/2a Cell wall teichoic acid glycosylation protein gtcA (gtcA)
Sign In for Pricing
View Details 130868-ML490 100 µL
PAPSS2 (PAPS Synthase 2, PAPSS 2, 3'-phosphoadenosine 5'-phosphosulfate Synthase 2, ATPSK2, Bifunctional 3'-phosphoadenosine 5'-phosphosulfate Synthase 2, Sulfurylase Kinase 2, SK 2, SK2) (MaxLight 490)
Sign In for Pricing
View Details 