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Topoisomerase I inhibitor 6

Selected Variant

HY-146437

Size: 1 Each

Topoisomerase I inhibitor 6 (Compound 3) is a potent inhibitor of Topoisomerase I. Topoisomerase I inhibitor 6 is able to trap DNA-Top1 cleavage complex and found to be less cytotoxic in non-cancerous cell line. Topoisomerase I inhibitor 6 has the potential for the research of cancer diseases[1].

Product Specifications

CAS Number

2393082-56-7

UNSPSC

12352005

Target

Topoisomerase

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/topoisomerase-i-inhibitor-6.html

Solubility

10 mM in DMSO

Smiles

NC1=CC=C(C=C1)C2=CC=C3N=CC(C4=NN=CO4)=C(C3=C2)NCCCN5C=CN=C5

Molecular Formula

C23H21N7O

Molecular Weight

411.46

References & Citations

[1]Kundu B, et al. Development of a metabolically stable topoisomerase I poison as anticancer agent. Eur J Med Chem. 2020 Sep 15;202:112551. doi: 10.1016/j.ejmech.2020.112551.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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