Antitumor agent-60
Product Specifications
UNSPSC Description
Antitumor agent-60 (compound 20) is a potent antitumor agent, targeting RAS-RAF signaling pathway and binding to CRAF with a Kd value of 3.93 μM. Antitumor agent-60 induces apoptosis by blocking cell cycle at G2/M phase. Antitumor agent-60 enhances the level of p53 and ROS. Antitumor agent-60 causes oval and irregular nucleus in cancer cells. Antitumor agent-60 can suppress the growth of tumor to some extent in A549 xenograft model[1].
Target Antigen
Apoptosis; MDM-2/p53; Raf; Ras; ROS Kinase
Type
Reference compound
Related Pathways
Apoptosis;GPCR/G Protein;MAPK/ERK Pathway;Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/antitumor-agent-60.html
Solubility
10 mM in DMSO
Smiles
COC1=CC(OC)=C(C(OC)=C1)/C=C/S(=O)(CC2=CC=C(C(OC(CCCC(O)=O)=O)=C2)OC)=O
Molecular Weight
508.54
References & Citations
[1]Liu Z, et al. Targeting RAS-RAF pathway significantly improves antitumor activity of Rigosertib-derived platinum(IV) complexes and overcomes cisplatin resistance. Eur J Med Chem. 2020;194:112269.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-146432/Antitumor-agent-60-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-146432/
Clinical Information
No Development Reported
CAS Number
9007-83-4
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