Antitumor agent-60

Antitumor agent-60 (compound 20) is a potent antitumor agent, targeting RAS-RAF signaling pathway and binding to CRAF with a Kd value of 3.93 μM. Antitumor agent-60 induces apoptosis by blocking cell cycle at G2/M phase. Antitumor agent-60 enhances the level of p53 and ROS. Antitumor agent-60 causes oval and irregular nucleus in cancer cells. Antitumor agent-60 can suppress the growth of tumor to some extent in A549 xenograft model[1].

Product Specifications

CAS Number

[865784-65-2]

UNSPSC

12352005

Target

Apoptosis; MDM-2/p53; Raf; Ras; ROS Kinase

Type

Reference compound

Related Pathways

Apoptosis; GPCR/G Protein; MAPK/ERK Pathway; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/antitumor-agent-60.html

Solubility

10 mM in DMSO

Smiles

COC1=CC(OC)=C(C(OC)=C1)/C=C/S(=O)(CC2=CC=C(C(OC(CCCC(O)=O)=O)=C2)OC)=O

Molecular Formula

C24H28O10S

Molecular Weight

508.54

References & Citations

[1]Liu Z, et al. Targeting RAS-RAF pathway significantly improves antitumor activity of Rigosertib-derived platinum (IV) complexes and overcomes cisplatin resistance. Eur J Med Chem. 2020;194:112269.