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AT2R antagonist 1

AT2R antagonist 1 (compound 21) is a potent and high selective AT2R (angiotensin II AT2 receptor) ligand. AT2R antagonist 1 exhibits a fair AT2R affinity, with a Ki of 29 nM. AT2R antagonist 1 also inhibits common agent-metabolizing CYP enzymes. AT2R antagonist 1 shows high stability in human, rat and mouse liver microsomes[1].

Product Specifications

CAS Number

2709031-17-2

UNSPSC

12352005

Target

Angiotensin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Neuroscience-Neuromodulation

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/at2r-antagonist-1.html

Solubility

10 mM in DMSO

Smiles

COC(NS(=O)(C1=C(N=C(S1)CC(C)C)C2=CC=C(C=C2)CN3C=CN=C3C(C)(C)C)=O)=O

Molecular Formula

C23H30N4O4S2

Molecular Weight

490.64

References & Citations

[1]Bolteau R, et al. Quinazoline and phthalazine derivatives as novel melatonin receptor ligands analogues of agomelatine. Eur J Med Chem. 2020 Mar 1;189:112078.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

AT2 Receptor

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