AT2R antagonist 1
AT2R antagonist 1 (compound 21) is a potent and high selective AT2R (angiotensin II AT2 receptor) ligand. AT2R antagonist 1 exhibits a fair AT2R affinity, with a Ki of 29 nM. AT2R antagonist 1 also inhibits common agent-metabolizing CYP enzymes. AT2R antagonist 1 shows high stability in human, rat and mouse liver microsomes[1].
Product Specifications
CAS Number
2709031-17-2
UNSPSC
12352005
Target
Angiotensin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/at2r-antagonist-1.html
Solubility
10 mM in DMSO
Smiles
COC(NS(=O)(C1=C(N=C(S1)CC(C)C)C2=CC=C(C=C2)CN3C=CN=C3C(C)(C)C)=O)=O
Molecular Formula
C23H30N4O4S2
Molecular Weight
490.64
References & Citations
[1]Bolteau R, et al. Quinazoline and phthalazine derivatives as novel melatonin receptor ligands analogues of agomelatine. Eur J Med Chem. 2020 Mar 1;189:112078.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AT2 Receptor
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNC400857-100 1x 100 µL
WT1 (Wilm's Tumor 1) (WT1/857), CF640R conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC941648-100 1x 100 µL
TIMP1 (Marker of Lymph Node Metastasis) (2A5), CF594 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 