NAChR antagonist 1
NAChR antagonist 1 (compound B15) is an excellent α7 nAChR antagonist with an IC50 value of 3.3 μM. nAChR antagonist 1 can be used for researching schizophrenia, Alzheimer’s disease and inflammatory disorders[1].
Product Specifications
CAS Number
2987393-37-1
UNSPSC
12352005
Target
NAChR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/nachr-antagonist-1.html
Solubility
10 mM in DMSO
Smiles
COC1=CC(C2=CC=C(C=C2)C3=NOC4(N3)CCN(CC4)C)=CC=N1
Molecular Formula
C19H22N4O2
Molecular Weight
338.40
References & Citations
[1]Zhang H, et al. Design, synthesis and biological activities of piperidine-spirooxadiazole derivatives as α7 nicotinic receptor antagonists. Eur J Med Chem. 2020;207:112774.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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