CXCR4 antagonist 6
CXCR4 antagonist 6 (compound 46) is a potent CXCR4 antagonist with an IC50 value of 79 nM. CXCR4 antagonist 6 inhibits CXCL12 induced cytosolic calcium flux (IC50 = 0.25 nM) . CXCR4 antagonist 6 significantly mitigates CXCL12/CXCR4 mediated cell migration. CXCR4 antagonist 6 exhibits marked efficacy in a cancer metastasis model in mice[1].
Product Specifications
CAS Number
2304750-68-1
UNSPSC
12352005
Target
CXCR
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cxcr4-antagonist-6.html
Solubility
10 mM in DMSO
Smiles
CC1=CC=CN=C1[C@@H]2CCCN2CC3=NC(C)=NC(N4CCN(CC4)C)=C3
Molecular Formula
C21H30N6
Molecular Weight
366.50
References & Citations
[1]Li Z, et al. Design, synthesis, and evaluation of pyrrolidine based CXCR4 antagonists with in vivo anti-tumor metastatic activity. Eur J Med Chem. 2020;205:112537.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CXCR4
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