SIRT5 inhibitor 2
SIRT5 inhibitor 2 (compound 49) is a potent SIRT5 inhibitor with an IC50 value of 2.3 μM. SIRT5 inhibitor 2 has inhibitory activity against the SIRT5-dependent desuccinylation. SIRT5 inhibitor 2 can be used for researching cancer and neurodegenerative diseases[1].
Product Specifications
CAS Number
[340306-87-8]
UNSPSC
12352005
Target
Sirtuin
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/sirt5-inhibitor-2.html
Solubility
10 mM in DMSO
Smiles
C=CCN1C(/C(C(NC1=S)=O)=C/C2=CC=C(O2)C3=CC=CC(Cl)=C3Cl)=O
Molecular Formula
C18H12Cl2N2O3S
Molecular Weight
407.27
References & Citations
[1]Wang Y, et al. Overview of SIRT5 as a potential therapeutic target: Structure, function and inhibitors. Eur J Med Chem. 2022;236:114363.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
SIRT5
Available Sizes
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