CRM1 degrader 1
CRM1 degrader 1 (1l) is a low toxic chromosome region maintenance 1 (CRM1) degrader. CRM1 is the sole nuclear exporter of several tumor suppressor, a growth regulatory protein as an attractive cancer agent target. CRM1 degrader 1 induces the apoptosis in gastric carcinoma and selectively inhibits proliferation of gastric cancer[1].
Product Specifications
CAS Number
2986647-41-8
UNSPSC
12352005
Target
CRM1
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/crm1-degrader-1.html
Solubility
10 mM in DMSO
Smiles
CC1=CC(OC[C@H]2CC=CC(O2)=O)=C(C=C1)C(C)C
Molecular Formula
C16H20O3
Molecular Weight
260.33
References & Citations
[1]Xu HW, et al. A low toxic CRM1 degrader: Synthesis and anti-proliferation on MGC803 and HGC27. Eur J Med Chem. 2020;206:112708.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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